Does TRAMADOL HCL ER Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • TRAMADOL/MAOIS
  • PROPOXYPHENE; TRAMADOL/RASAGILINE; SELEGILINE
  • SLT SEROTONERGIC OPIOIDS (EXTENDED RELEASE)/METAXALONE
  • SLT SEROTONERGIC OPIOIDS (IMMEDIATE RELEASE)/METAXALONE
  • SEROTONINERGIC AGENTS/DAPOXETINE
  • OPIOID ANALGESICS/OPIOID ANTAGONISTS
  • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • CHRONIC OPIOIDS/NALBUPHINE
  • TRAMADOL/LINEZOLID
  • CHRONIC OPIOIDS/BUTORPHANOL
  • CHRONIC OPIOIDS/BUPRENORPHINE
  • TRAMADOL/MEPERIDINE
  • TRAMADOL/TRICYCLIC COMPOUNDS; CARBAMAZEPINE
  • TRAMADOL/CYCLOBENZAPRINE
  • ANTICHOLINERGICS; OPIOIDS/ELUXADOLINE
  • AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 123
  • AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 131
  • CODEINE; TRAMADOL/SODIUM OXYBATE
  • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • OPIOIDS/BUPRENORPHINE
  • TRAMADOL/5-HT3 ANTAGONISTS
  • OPIOIDS/BUTORPHANOL
  • OPIOIDS/NALBUPHINE
  • TRAMADOL/SELECTED MODERATE TO STRONG CYP2D6 INHIBITORS
  • OPIOIDS (EXTENDED RELEASE)/BENZODIAZEPINES
  • OPIOIDS (IMMEDIATE RELEASE)/BENZODIAZEPINES
  • OPIOIDS (EXTENDED RELEASE)/SLEEP DRUGS; TRANQUILIZERS
  • OPIOIDS (IMMEDIATE RELEASE)/SLEEP DRUGS; TRANQUILIZERS
  • OPIOIDS (EXTENDED RELEASE)/MUSCLE RELAXANTS
  • OPIOIDS (IMMEDIATE RELEASE)/MUSCLE RELAXANTS
  • OPIOIDS (EXTENDED RELEASE)/ANTIPSYCHOTICS; PHENOTHIAZINES
  • TRAMADOL (IR)/SELECTED ANTIPSYCHOTICS; PHENOTHIAZINES
  • TRAMADOL (IR)/SELECTED ANTIPSYCHOTICS; PHENOTHIAZINES
  • OPIOIDS (IMMEDIATE RELEASE)/SELECTED STIMULANTS
  • OPIOIDS (EXTENDED RELEASE)/SELECTED STIMULANTS
  • TRAMADOL/SELECTED SSRIS; SNRIS
  • AGENTS WITH HYPONATREMIA RISK/DESMOPRESSIN
  • MEPERIDINE; TRAMADOL/TRAZODONE (<= 50 MG)
  • TRAMADOL/AMPHETAMINES
  • AGENTS WITH HYPONATREMIA RISK/DESMOPRESSIN (NOCTURIA)
  • MEPERIDINE; TRAMADOL/NEFAZODONE; TRAZODONE (> 50 MG)
  • OPIOIDS (IR & ER)/GABAPENTINOIDS
  • PROPOXYPHENE; TRAMADOL/SLT ANTICOAGULANTS (VIT K ANTAG)
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.