Stavudine/Zidovudine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Zidovudine may decrease the transformation of stavudine to its active form.

What might happen:

The levels of the active form of stavudine in your blood may decrease and it may not be as effective.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your medicine may need to be changed.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Hoggard P, Khoo S, Barry M, Back D. Intracellular metabolism of zidovudine and stavudine in combination. J Infect Dis 1996 Sep;174(3):671-2.
  • 2.Havlir DV, Tierney C, Friedland GH, Pollard RB, Smeaton L, Sommadossi JP, Fox L, Kessler H, Fife KH, Richman DD. In vivo antagonism with zidovudine plus stavudine combination therapy. J Infect Dis 2000 Jul;182(1):321-5.
  • 3.Retrovir (zidovudine) US prescribing information. GlaxoSmithKline September, 2018.
  • 4.Zerit (stavudine) US prescribing information. Bristol-Myers Squibb Company December 19, 2017.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.