Who should not take Clozaril?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:

Conditions:

  • diabetes
  • excessive fat in the blood
  • low amount of magnesium in the blood
  • extreme loss of body water
  • low amount of potassium in the blood
  • overweight
  • decreased function of bone marrow
  • deficiency of granulocytes a type of white blood cell
  • increased eosinophils in the blood
  • abnormal movements of face
  • muscles
  • and tongue
  • neuroleptic malignant syndrome
  • lower seizure threshold
  • closed angle glaucoma
  • lung embolism
  • very rapid heartbeat - torsades de pointes
  • slow heartbeat
  • sinus tachycardia
  • prolonged QT interval on EKG
  • inflammation of the middle tissue heart muscle
  • abnormal EKG with QT changes from birth
  • stroke
  • disorder of the blood vessels of the brain
  • blood clot in a deep vein of the extremities
  • Blood Pressure Drop Upon Standing
  • abnormally low blood pressure
  • paralysis of the intestines
  • Impacted Stool
  • constipation
  • liver problems
  • Acute Inflammation of the Pancreas
  • Enlarged Prostate
  • seizures
  • weight gain
  • cannot empty bladder
  • abnormal liver function tests
  • Susceptible to Breathing Fluid Into Lungs
  • a mother who is producing milk and breastfeeding
  • Severely Decreased Levels of Neutrophils in the Blood
  • dilated cardiomyopathy
  • tobacco smoking
  • Metabolic Syndrome X
  • Dementia in an Elderly Person
  • decreased motility function of stomach or intestines
  • CYP2D6 poor metabolizer
  • reduced activity of cytochrome p450 CYP3A4
  • reduced activity of cytochrome p450 CYP1A2

Allergies:

  • Clozapine

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.