Who should not take Clozapine?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • diabetes
  • excessive fat in the blood
  • low amount of magnesium in the blood
  • dehydration
  • low amount of potassium in the blood
  • overweight
  • decreased function of bone marrow
  • low levels of a type of white blood cell called neutrophils
  • increased eosinophils in the blood
  • tardive dyskinesia, a disorder characterized by involuntary movements of the face, mouth and tongue
  • neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion
  • a low seizure threshold
  • closed angle glaucoma
  • heart attack within the last 30 days
  • a low supply of oxygen rich blood to the heart
  • a clot in the lung
  • cardiomyopathy, a disease of the heart muscle
  • torsades de pointes, a type of abnormal heart rhythm
  • slow heartbeat
  • sinus tachycardia, a type of fast heart rate
  • prolonged QT interval on EKG
  • inflammation of the middle tissue heart muscle
  • abnormal EKG with QT changes from birth
  • a stroke
  • a disorder of the blood vessels of the brain
  • blood clot in a deep vein of the extremities
  • orthostatic hypotension, a form of low blood pressure
  • low blood pressure
  • paralysis of the intestines
  • a blockage of the intestines with stool
  • constipation
  • liver problems
  • acute inflammation of the pancreas
  • enlarged prostate
  • seizures
  • weight gain
  • an inability to completely empty the bladder
  • abnormal liver function tests
  • susceptible to breathing fluid into lungs
  • a patient who is producing milk and breastfeeding
  • tobacco smoking
  • metabolic syndrome x
  • dementia in an elderly person
  • the stomach and intestines to move food at a slower pace
  • CYP2D6 poor metabolizer
  • reduced activity of cytochrome p450 CYP3A4
  • reduced activity of cytochrome p450 CYP1A2
  • obstruction of intestine

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.