CLOZAPINE Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • orthostatic hypotension, a form of low blood pressure
  • low blood pressure

If experienced, these tend to have a Less Severe expression i

  • a change in vision
  • excessive saliva production
  • dry mouth
  • drowsiness
  • inducing of a relaxed easy state
  • sensation of spinning or whirling
  • dizziness
  • excessive sweating
  • weight gain
  • headache
  • nausea
  • vomiting

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • low levels of a type of white blood cell called neutrophils
  • high blood pressure
  • abnormal heart rhythm
  • a feeling of restlessness with inability to sit still

If experienced, these tend to have a Less Severe expression i

  • nightmares
  • inflammation of the parotid gland
  • indigestion
  • low energy
  • a skin rash
  • heartburn
  • burping
  • diarrhea
  • an inability to completely empty the bladder
  • abdominal bloating
  • nervousness
  • intense abdominal pain

RARE side effects

If experienced, these tend to have a Severe expression i

  • a systemic inflammatory response called sepsis due to an infection with bacteria
  • an infection
  • a complication of diabetes with high blood ketone levels called diabetic ketoacidosis
  • diabetic hyperosmolar coma
  • diabetes
  • low amount of sodium in the blood
  • decreased blood platelets
  • very low levels of granulocytes, a type of white blood cell
  • low levels of white blood cells
  • low levels of granulocytes, a type of white blood cell
  • increased eosinophils in the blood
  • a blood disorder
  • increase in the number of platelets in the blood
  • myoclonus, quick and involuntary muscle jerks
  • tardive dyskinesia, a disorder characterized by involuntary movements of the face, mouth and tongue
  • extrapyramidal disease, a type of movement disorder
  • neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion
  • repeated seizures with unconsciousness between episodes
  • cataplexy, an attack of total body muscle weakness
  • a heart attack
  • a clot in the lung
  • inflammation of the covering of the heart or pericardium
  • fluid in the covering of the heart or pericardium
  • cardiomyopathy, a disease of the heart muscle
  • abnormal heart electrical signals
  • rapid ventricular heartbeat
  • torsades de pointes, a type of abnormal heart rhythm
  • atrial fibrillation
  • ventricular fibrillation, a heart rhythm disorder
  • slow heartbeat
  • prolonged QT interval on EKG
  • chronic heart failure
  • inflammation of the middle tissue heart muscle
  • allergic reaction causing inflammation of blood vessels
  • inflammation of the blood vessels
  • blood clot in a deep vein of the extremities
  • pneumonia
  • pneumonia due to accidental inhalation of vomit
  • a lower respiratory infection
  • a stomach ulcer
  • necrotizing enterocolitis, or inflammation and tissue death in the colon and small intestine
  • inflammation of the large intestine
  • paralysis of the intestines
  • blocked bowels with decreased peristaltic movement
  • a blockage of the intestines with stool
  • blockage of the stomach or intestine
  • liver tissue death
  • hardening of the liver
  • enlarged fatty liver
  • liver failure
  • inflammation of the liver called hepatitis
  • blockage of normal bile flow
  • acute inflammation of the pancreas
  • a type of kidney inflammation called interstitial nephritis
  • acute kidney failure
  • kidney failure
  • priapism, a prolonged erection of the penis
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • systemic lupus erythematosus, an autoimmune disease
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • muscle stiffness
  • seizures
  • diminished movement
  • high blood sugar
  • abnormal liver function tests
  • a type of allergic reaction called angioedema
  • secondary angle-closure glaucoma, a type of eye disorder
  • accidental falls
  • a yellowing of the eyes or skin from buildup of bilirubin called jaundice
  • the stomach and intestines to move food at a slower pace
  • tissue death or necrosis in the intestinal colon
  • high levels of hemoglobin
  • inflammation of the serous membranes in the body
  • a type of significant allergic skin reaction called DRESS syndrome
  • mitral valve regurgitation

If experienced, these tend to have a Less Severe expression i

  • high cholesterol
  • high amount of triglyceride in the blood
  • fluid accumulation around the eye
  • angina, a type of chest pain
  • breast pain
  • pain with menstruation
  • increased sensitivity of the skin to the sun
  • skin discoloration
  • muscle weakness
  • taste impairment
  • loss of muscle coordination
  • visible water retention
  • decreased appetite
  • weight loss
  • excessive thirst
  • slurred speech
  • a type of speech disorder called dysarthria
  • difficulty swallowing
  • involuntary leakage of urine
  • bedwetting
  • high amount of uric acid in the blood
  • a feeling of pins and needles on skin
  • low energy and weakness

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.