This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Rifampin may speed up how quickly your liver processes your heart medicine.
What might happen:
The amount of heart medicine in your blood may decrease and it may not work as well.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you experience an irregular or unusually fast heartbeat.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Cordarone (amiodarone hydrochloride) US prescribing information. Wyeth Pharmaceuticals April 7, 2017.
2.Multaq (dronedarone) US prescribing information. Sanofi-Aventis U.S. LLC January, 2014.
3.Zarembski DG, Fischer SA, Santucci PA, Porter MT, Costanzo MR, Trohman RG. Impact of rifampin on serum amiodarone concentrations in a patient with congenital heart disease. Pharmacotherapy 1999 Feb;19(2):249-51.