Clozapine/Selected Myelosuppressive Agents Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of these medicines can affect your bone marrow's ability to make new white blood cells.

What might happen:

If white blood cells are too low (also called the ANC or absolute neutrophil count), your risk for infection is increased.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your doctor may need to change one of your medicines or may need to check your blood frequently to be sure your white blood cells are in a safe range. It is important that you keep laboratory appointments.You should contact your healthcare provider right away if you have symptoms of infection such as a fever, sore throat or flu-like symptoms.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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