Digoxin, Oral/Antineoplastics Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the amount of digoxin absorbed by your body may decrease.

What might happen:

Your digoxin blood level may decrease and cause a decrease in the beneficial effects on your heart.

What you should do about this interaction:

If your doctor prescribes these medicines together, you may need to have your blood level of digoxin measured more regularly. Your doctor may need to adjust the dose.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Kuhlmann J, Zilly W, Wilke J. Effects of cytostatic drugs on plasma level and renal excretion of beta- acetyldigoxin. Clin Pharmacol Ther 1981 Oct; 30(4):518-27.
  • 2.Kuhlmann J, Wilke J, Rietbrock N. Cytostatic drugs are without significant effect on digitoxin plasma level and renal excretion. Clin Pharmacol Ther 1982 Nov;32(5):646-51.
  • 3.Bjornsson TD, Huang AT, Roth P, Jacob DS, Christenson R. Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations. Clin Pharmacol Ther 1986 Jan;39(1):25-8.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.