PREMARIN Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • enlarged breasts
  • breast pain

If experienced, these tend to have a Less Severe expression i

  • headache
  • abdominal bloating
  • intense abdominal pain

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • inflammation of the lining of the stomach and intestines
  • backache
  • weight gain

If experienced, these tend to have a Less Severe expression i

  • a yeast infection of the vagina and vulva
  • an infection due to the fungus Candida
  • water retention
  • a migraine headache
  • constipation
  • inflammation or infection of the vagina
  • vaginal discharge
  • pain with menstruation
  • joint pain
  • muscle pain
  • leg cramps
  • dizziness
  • difficulty sleeping
  • increased hunger
  • nausea
  • gas
  • diarrhea
  • generalized weakness
  • anxious feelings

RARE side effects

If experienced, these tend to have a Severe expression i

  • uterine fibroids
  • cancer of the ovary
  • cancer in the lining of the uterus
  • a breast tumor
  • dementia
  • depression
  • a clot in the small veins that carry blood to or from the retina of the eye
  • high blood pressure
  • a heart attack
  • a clot in the lung
  • a stroke
  • obstruction of a blood vessel by a blood clot
  • thrombophlebitis, an inflamed vein due to a blood clot
  • blood clot formation in veins
  • low blood pressure
  • a common cold
  • the flu
  • worsening asthma
  • insufficient blood supply to the colon
  • inflammation of the liver called hepatitis
  • a blockage in the gallbladder
  • acute inflammation of the pancreas
  • a lump in the breast
  • fluid secretion from the breast
  • overgrowth of the uterine lining
  • absence of menstrual periods
  • abnormally long or heavy periods
  • bleeding not related to menstrual period
  • erythema multiforme, a type of allergic skin reaction
  • erythema nodosum, a skin condition with red and painful nodules
  • hives
  • a skin rash
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • involuntary muscle movements

If experienced, these tend to have a Less Severe expression i

  • high amount of triglyceride in the blood
  • mood changes
  • altered interest in having sexual intercourse
  • keratoconus, or protrusion of the cornea of the eye
  • itching
  • hair loss
  • hirsutism, a condition of hair growth on parts of the body normally without hair
  • yellow-brown patches on skin
  • weight loss
  • vomiting
  • pelvic pain
  • nervousness

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.