Dyphylline/Probenecid Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When you take these two medicines together, your body may not process your asthma medicine properly.

What might happen:

Your blood level of asthma medicine may increase and cause toxic effects.

What you should do about this interaction:

If you experience chest pain, rapid or irregular heartbeat, confusion, loss of appetite, nausea, vomiting, or breathing difficulties, contact your doctor. Your doctor may need to adjust the dose of your asthma medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.May DC, Jarboe CH. Effect of probenecid on dyphylline elimination. Clin Pharmacol Ther 1983 Jun;33(6):822-5.
  • 2.Chen TW, Patton TF. Effect of probenecid on the pharmacokinetics of aminophylline. Drug Intell Clin Pharm 1983 Jun;17(6):465-6.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.