Neuromuscular Blocking Agents/Verapamil Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known.

What might happen:

The effects of the nondepolarizing muscle relaxant will last for a longer time.

What you should do about this interaction:

The nondepolarizing muscle relaxant group of drugs is only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription and non-prescription medicine, herbal medicines, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.van Poorten JF, Dhasmana KM, Kuypers RS, Erdmann W. Verapamil and reversal of vecuronium neuromuscular blockade. Anesth Analg 1984 Feb;63(2):155-7.
  • 2.Jones RM, Cashman JN, Casson WR, Broadbent MP. Verapamil potentiation of neuromuscular blockade: failure of reversal with neostigmine but prompt reversal with edrophonium. Anesth Analg 1985 Oct;64(10):1021-5.
  • 3.Carlos R, Erill S. Therapeutic rounds: abnormally prolonged responses to neuromuscular blocking agents. Clin Ther 1986;9(1):22-3, 135-6.
  • 4.Wali FA. Interaction of verapamil with d-tubocurarine and cholinergic agonists at the avian neuromuscular junction. Acta Anaesthesiol Scand 1987 Jan;31(1):15-20.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.