Does Interact with other Medications?
Severe Interactions
These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
- SYMPATHOMIMETICS (INDIRECT & MIXED ACTING)/MAOIS
- SELECTED CYP1A2 SUBSTRATES/VILOXAZINE
- UGT1A1 INDUCERS/CABOTEGRAVIR
- CYP3A4 & UGT1A1 INDUCERS/CABOTEGRAVIR-RILPIVIRINE
- STRONG AND MODERATE CYP3A4 INDUCERS/LONAFARNIB
- STRONG CYP3A4 INDUCERS/FOSTEMSAVIR
- STRONG CYP3A4 INDUCERS/TAMOXIFEN
- STRONG CYP3A4 INDUCERS/LORLATINIB
- CYP3A4 INDUCERS/DORAVIRINE
- SELECTED CYP3A4 INDUCERS/ATAZANAVIR-COBICISTAT
- STR CYP3A4 & P-GP INDUCER;PHENOBARB/GLECAPREVIR-PIBRENTASVIR
- SELECTED CYP3A4 INDUCERS/COBICISTAT-ELVITEGRAVIR
- STRONG CYP3A4 INDUCERS/ELBASVIR-GRAZOPREVIR
- STRONG CYP3A4 INDUCERS/DELAMANID
- SLT MODERATE-STRONG CYP3A4 INDUCERS/SLT HEPATITIS C AGENTS
- STRONG CYP3A4 INDUCERS/DACLATASVIR
- P-GP INDUCERS; PHENOBARBITAL/SELECTED HEPATITIS C AGENTS
- PDE INHIBITORS/RIOCIGUAT
- STRONG CYP3A4 INDUCERS/ARTEMETHER; LUMEFANTRINE
- CYP3A4 INDUCERS/RILPIVIRINE
- CYP3A4 INDUCERS/BOCEPREVIR; COBICISTAT; TELAPREVIR
- STRONG CYP3A4 INDUCERS/LURASIDONE
- SELECTED STRONG CYP3A4 INDUCERS/PRAZIQUANTEL
- STRONG CYP3A4 INDUCERS/RANOLAZINE
- SLT STRONG 3A4 INDUCERS/NIFEDIPINE; NIMODIPINE; NISOLDIPINE
- SEDATIVE HYPNOTICS; ALCOHOL/SODIUM OXYBATE
- SELECTED CYP3A4 INDUCERS/ISAVUCONAZONIUM; VORICONAZOLE
- SELECTED STRONG CYP3A4 INDUCERS/DELAVIRDINE; ETRAVIRINE
- XANTHINE DERIVATIVES/DIPYRIDAMOLE INJECTABLE
Serious Interactions
These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
- THEOPHYLLINE DERIVATIVES/CIMETIDINE
- SELECT INDIRECT-ACTING SYMPATHOMIMETICS/TRICYCLIC COMPOUNDS
- SELECTED ANTICONVULSANTS; BARBITURATES/CONTRACEPTIVES
- THEOPHYLLINES/SELECTED QUINOLONES
- THEOPHYLLINES/HALOTHANE
- THEOPHYLLINES/ALLOPURINOL
- THEOPHYLLINES/CARBAMAZEPINE
- THEOPHYLLINES/TACRINE
- THEOPHYLLINE/RIFAMYCINS
- SELECTED ANTICONVULSANTS; BARBITURATES/TELITHROMYCIN
- SELECTED ANTICONVULSANTS; BARBITURATES/SLT AZOLE ANTIFUNGALS
- BARBITURATES;PHENOBARBITAL;PHENYTOIN/SLT PROTEASE INHIBITORS
- MIXED;INDIRECT SYMPATHOMIMETICS/SELECTED MAOIS
- SELECTED CYP1A2 SUBSTRATES/VEMURAFENIB
- THEOPHYLLINE;TIZANIDINE/DEFERASIROX
- SELECTED CYP1A2 SUBSTRATES/CAPMATINIB
- STRONG OR MODERATE CYP3A4 INDUCERS/AVACOPAN
- STRONG OR MODERATE CYP3A4 INDUCERS/MOBOCERTINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/FEXINIDAZOLE
- STRONG AND MODERATE CYP3A4 INDUCERS/FINERENONE
- STRONG AND MODERATE CYP3A4 INDUCERS/IBREXAFUNGERP
- STRONG CYP3A4 INDUCERS/SAMIDORPHAN
- STRONG AND MODERATE CYP3A4 INDUCERS/INFIGRATINIB
- STRONG CYP3A4 INDUCERS/SOTORASIB
- SELECTED STRONG CYP3A4 INDUCERS/APREPITANT; NETUPITANT
- STRONG CYP3A4 INDUCERS/TEPOTINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/VOCLOSPORIN
- PDE INHIBITORS/VERICIGUAT
- STRONG CYP3A4 INDUCERS/LUMACAFTOR-IVACAFTOR
- STRONG CYP3A4 INDUCERS/PRALSETINIB
- STRONG CYP3A4 INDUCERS/PLITIDEPSIN
- SELECTED UGT1A1 INDUCERS/RALTEGRAVIR
- STRONG AND MODERATE CYP3A4 INDUCERS/LURBINECTEDIN
- STRONG CYP3A4 INDUCERS/RIPRETINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/SELPERCATINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/CAPMATINIB
- UGT1A1 INDUCERS/SACITUZUMAB GOVITECAN
- STRONG CYP3A4 INDUCERS; MODERATE CYP2C8 INDUCERS/TUCATINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/PEMIGATINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/SELUMETINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/RIMEGEPANT
- STRONG OR MODERATE CYP3A4 INDUCERS/TAZEMETOSTAT
- STRONG CYP3A4 INDUCERS/REGORAFENIB
- STRONG OR MODERATE CYP3A4 INDUCERS/AVAPRITINIB
- CYP3A4 INDUCERS/LUMATEPERONE
- STRONG OR MODERATE CYP3A4 INDUCERS/LEMBOREXANT
- STRONG CYP3A4 INDUCERS/UBROGEPANT
- SELECTED STRONG OR MODERATE CYP3A4 INDUCERS/VOXELOTOR
- STRONG OR MODERATE CYP3A4 INDUCERS/ZANUBRUTINIB
- P-GLYCOPROTEIN (P-GP) OR UGT INDUCERS/LETERMOVIR
- SELECTED STRONG CYP3A4 INDUCERS/ISTRADEFYLLINE
- STRONG CYP3A4 OR P-GLYCOPROTEIN (P-GP) INDUCER/LEFAMULIN
- STRONG CYP3A4 INDUCERS/FEDRATINIB
- STRONG CYP3A4 INDUCERS/UPADACITINIB
- STRONG CYP3A4 INDUCERS/ENTRECTINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/PRETOMANID
- STRONG CYP3A4 INDUCERS/PEXIDARTINIB
- SELECTED STRONG CYP3A4 INDUCERS; RIFABUTIN/BICTEGRAVIR
- STRONG CYP3A4 INDUCERS/TIVOZANIB
- STRONG CYP3A4 INDUCERS/ERDAFITINIB
- SELECTED MODERATE AND STRONG CYP3A4 INDUCERS/SIPONIMOD
- STRONG CYP3A4 INDUCERS; RIFABUTIN/LAROTRECTINIB
- STRONG CYP3A4 INDUCERS/GLASDEGIB
- STRONG CYP3A4 INDUCERS/DUVELISIB
- STRONG CYP3A4 INDUCERS/ERAVACYCLINE
- AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 123
- AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 131
- STRONG CYP3A4 INDUCERS/IVOSIDENIB
- STRONG CYP3A4 INDUCER/SLT LONG-ACTING ARIPIPRAZOLE INJECTION
- STRONG AND MODERATE CYP3A4 INDUCERS/ENCORAFENIB
- SELECTED BARBITURATES/SELECTED ANTICONVULSANTS
- SELECTED BARBITURATES/LAMOTRIGINE
- SELECTED BARBITURATES/ESLICARBAZEPINE
- SELECTED BARBITURATES/CARBAMAZEPINE
- STRONG CYP3A4 INDUCERS/MACIMORELIN
- STRONG CYP3A4 INDUCERS/ACALABRUTINIB
- STRONG CYP3A4 INDUCERS/ABEMACICLIB
- STRONG CYP3A4 INDUCERS/COPANLISIB
- STRONG AND MODERATE CYP3A4 INDUCERS/NERATINIB
- STRONG CYP3A4 INDUCERS; RIFABUTIN/BRIGATINIB
- STRONG CYP3A4 INDUCERS/MIDOSTAURIN
- STRONG CYP3A4 INDUCERS/NALDEMEDINE
- STRONG CYP3A4 INDUCERS/RIBOCICLIB
- STRONG CYP3A4 INDUCERS/VENETOCLAX
- STRONG CYP3A4 INDUCERS; RIFABUTIN/VEMURAFENIB
- STRONG CYP3A4 INDUCERS/TOFACITINIB
- SLT MODERATE AND STRONG CYP3A4 INDUCERS/IXAZOMIB
- STRONG CYP3A4 INDUCERS/OSIMERTINIB
- STRONG CYP3A4 INDUCERS/TRABECTEDIN
- STRONG CYP3A4 INDUCERS/FLIBANSERIN
- STRONG CYP3A4 INDUCERS/SELECTED ANTINEOPLASTICS
- STRONG CYP3A4 INDUCERS/NALOXEGOL
- STRONG CYP3A4 INDUCERS/ELIGLUSTAT
- STRONG CYP3A4 INDUCERS/RAMELTEON; SUVOREXANT; TASIMELTEON
- STRONG CYP3A4 INDUCERS/QUETIAPINE (> 150 MG)
- STRONG & MODERATE CYP3A4 INDUCERS/GUANFACINE
- STRONG OR MODERATE CYP3A4 INDUCERS/SIMEPREVIR
- SELECTED UGT1 & CYP3A4 INDUCERS/DOLUTEGRAVIR
- UGT INDUCERS/CANAGLIFLOZIN
- STRONG & MODERATE CYP3A4 INDUCERS/BEDAQUILINE
- STRONG CYP3A4 INDUCERS; RIFABUTIN/PONATINIB
- STRONG & MODERATE CYP2C8 OR CYP3A4 INDUCERS/ENZALUTAMIDE
- SELECTED STRONG CYP3A4 INDUCERS/BORTEZOMIB
- STRONG CYP3A4 INDUCERS/IVACAFTOR
- STRONG & MODERATE CYP3A4 INDUCERS/SELECTED ANTINEOPLASTICS
- P-GP & STRONG 3A4 INDUCERS;EFAVIRENZ;PB/APIXABAN;RIVAROXABAN
- STRONG CYP3A4 INDUCERS/TOREMIFENE
- STRONG P-GP OR CYP3A4 INDUCER/LINAGLIPTIN
- STRONG CYP3A4 INDUCERS/TICAGRELOR; VORAPAXAR
- STRONG CYP3A4 INDUCERS/APREMILAST; ROFLUMILAST
- SELECTED STRONG CYP3A4 INDUCERS/IXABEPILONE
- STRONG CYP3A4 INDUCERS; RIFABUTIN/ROMIDEPSIN
- STRONG UGT INDUCERS/DEFERASIROX
- SELECTED STRONG CYP3A4 INDUCERS/ULIPRISTAL
- SELECTED STRONG CYP3A4 INDUCERS/AMIODARONE;DRONEDARONE
- STRONG CYP3A4 INDUCERS/TOLVAPTAN
- STRONG CYP3A4 INDUCERS/SELECTED IMMUNOSUPPRESSANTS
- SELECTED ANTICONVULSANTS; BARBITURATES/FESOTERODINE
- STRONG CYP3A4 INDUCERS/MARAVIROC
- STRONG CYP3A4 INDUCERS/MACITENTAN
- SELECTED STRONG CYP3A4 INDUCERS/IRINOTECAN
- SELECTED STRONG CYP3A4 INDUCERS/DARUNAVIR
- SELECTED ANTICONVULSANTS/POSACONAZOLE
- STRONG 3A4 INDUCERS/SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB
- STRONG CYP3A4 INDUCERS/IVABRADINE
- STRONG CYP3A4 INDUCERS/EXEMESTANE
- STRONG CYP3A4 INDUCERS/ROLAPITANT
- SYMPATHOMIMETICS/SELECTED INHALATION ANESTHETIC AGENTS
- XANTHINE DERIVATIVES/ADENOSINE; HEXOBENDINE; REGADENOSON
- SYMPATHOMIMETICS (INDIRECT ACTING)/GUANETHIDINE
- BARBITURATES/METHOXYFLURANE
- SELECTED CYP1A2 AND CYP3A4 INDUCERS/CLOZAPINE
- SYMPATHOMIMETICS/ERGOT ALKALOIDS
- STR 3A4 INDUCER;SLT BARBITURATES,HYDANTOIN/SLT ANTIMALARIALS
- BARBITURATES/SELECTED ANTICOAGULANTS (VIT K ANTAGONISTS)
Moderate Interactions
These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
- SYMPATHOMIMETICS/URINARY ALKALINIZERS
- SELECTED XANTHINE DERIVATIVES/SELECTED MACROLIDE ANTIBIOTICS
- SYMPATHOMIMETICS/RAUWOLFIA ALKALOIDS
- THEOPHYLLINE/ZILEUTON
- THEOPHYLLINE DERIVATIVES/LITHIUM
- SYMPATHOMIMETICS (DIRECT, MIXED-ACTING)/METHYLDOPA
- THEOPHYLLINES/THIABENDAZOLE
- SELECTED ANTICONVULSANTS; BARBITURATES/ESTROGENS
- XANTHINE DERIVATIVES/CHARCOAL
- SELECTED XANTHINE DERIVATIVES/FLUVOXAMINE
- SELECTED THEOPHYLLINE DERIVATIVES/MORICIZINE
- THEOPHYLLINE/FEBUXOSTAT
- BARBITURATES/PHENOTHIAZINES
- THEOPHYLLINE/MARIJUANA SMOKE
- THEOPHYLLINE DERIVATIVES/SELECTED CYP1A2 INHIBITORS
- SELECTED CYP1A2 SUBSTRATES/OBETICHOLIC ACID
- SELECTED CYP1A2 OR CYP2D6 SUBSTRATES/GIVOSIRAN
- SELECTED CYP1A2 SUBSTRATES/OSILODROSTAT
- STRONG CYP3A4 INDUCERS/SURUFATINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/ATOGEPANT
- STRONG CYP3A4 INDUCERS/BELUMOSUDIL
- BARBITURATES/HALOPERIDOL
- THEOPHYLLINE DERIVATIVES/FAVIPIRAVIR
- BETA-AGONISTS; ANTICHOLINERGICS; THEOPHYLLINE/METHACHOLINE
- STRONG UGT INDUCERS; NEVIRAPINE/ARTESUNATE
- STRONG CYP3A4 INDUCERS/CANNABIDIOL; TETRAHYDROCANNABINOL
- STRONG CYP3A4 INDUCERS/PITOLISANT
- BARBITURATES/RIFAMPIN
- STRONG CYP3A4 INDUCERS/FOSTAMATINIB
- STRONG AND MODERATE CYP3A4 INDUCERS/PERAMPANEL
- STRONG CYP3A4 INDUCERS/VALBENAZINE
- BARBITURATES/SELECTED BENZODIAZEPINES
- SELECTED STRONG CYP3A4 INDUCERS/CLARITHROMYCIN; ERYTHROMYCIN
- STRONG AND MODERATE CYP3A4 INDUCERS/PIMAVANSERIN
- SELECTED P-GP INDUCERS; PHENOBARBITAL/TENOFOVIR ALAFENAMIDE
- BARBITURATES; PHENOBARBITAL; PRIMIDONE/SELECTED OPIOIDS
- STRONG CYP3A4 INDUCERS/VILAZODONE
- P-GLYCOPROTEIN (P-GP) INDUCERS; PHENOBARBITAL/AFATINIB
- STRONG CYP3A4 INDUCERS/SELECT SEDATIVE HYPNOTICS; BUSPIRONE
- THEOPHYLLINE/BUPROPION
- SELECTED STRONG CYP3A4 INDUCERS/TIRILAZAD
- STRONG CYP3A4 INDUCERS/SELECTED ANTIPSYCHOTICS
- SELECTED ANTICONVULSANTS; BARBITURATES/FELODIPINE
- BARBITURATES/METRONIDAZOLE
- CYP3A4 INDUCERS/DOXYCYCLINE
- XANTHINE DERIVATIVES/CONTRACEPTIVES
- SELECTED CYP3A4 INDUCERS/CORTICOSTEROIDS
- BARBITURATES/SELECTED BETA-BLOCKERS
- THEOPHYLLINES/SELECTED BETA-BLOCKERS
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.