Ivacaftor/Strong CYP3A4 Inducers Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may speed up how quickly your liver processes ivacaftor.
What might happen:
The amount of ivacaftor in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you recently finished taking an inducer. Your doctor may want to adjust the dose of your ivacaftor while you are taking your other medicine or change your other medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Kalydeco (ivacaftor) US prescribing information. Vertex Pharmaceuticals Incorporated August, 2018.
- 2.Orkambi (lumacaftor, ivacaftor) US prescribing information. Vertex Pharmaceuticals Inc. August, 2018.
- 3.Symdeko (tezacaftor/ivacaftor) US prescribing information. Vertex Pharmaceuticals Incorporated February, 2018.
- 4.Trikafta (elexacaftor, tezacaftor and ivacaftor tablets; ivacaftor tablets) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2019.
- 5.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.