Methoxyflurane/Barbiturates Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are used together, your body processes methoxyflurane more quickly.

What might happen:

Toxic chemicals in your blood that are created from methoxyflurane may cause a harmful effect to your kidneys.

What you should do about this interaction:

Methoxyflurane is only used during surgical procedures or in a hospital. If you are scheduled to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that your healthcare professionals (e.g. doctor or pharmacist) are aware of all the medicines that you are taking. This includes prescription and non-prescription medicines, herbal drugs, and nutraceuticals.This interaction may occur if you take barbiturates just before or up to three weeks before being given methoxyflurane.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Son SL, Colella JJ Jr, Brown BR Jr. The effect of phenobarbitone on the metabolism of methoxyflurane to oxalic acid in the rat. Br J Anaesth 1972 Dec;44(12):1224-8.
  • 2.Cousins MJ, Mazze RI. Methoxyflurane nephrotoxicity. A study of dose response in man. JAMA 1973 Sep 24;225(13):1611-6.
  • 3.Cousins MJ, Mazze RI, Kosek JC, Hitt BA, Love FV. The etiology of methoxyflurane nephrotoxicity. J Pharmacol Exp Ther 1974 Sep; 190(3):530-41.
  • 4.Churchill D, Knaack J, Chirito E, Barre P, Cole C, Muehrcke R, Gault MH. Persisting renal insufficiency after methoxyflurane anesthesia. Report of two cases and review of literature. Am J Med 1974 Apr;56(4):575-82.
  • 5.Churchill D, Yacoub JM, Siu KP, Symes A, Gault MH. Toxic nephropathy after low-dose methoxyflurane anesthesia: drug interaction with secobarbital?. Can Med Assoc J 1976 Feb 21;114(4):326-8, 333.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.