Skip to content




    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    The cause of the interaction is unknown.

    What might happen:

    You may experience lithium toxicities that affect the nervous system. If you have other problems related to the nervous system you may be at greater risk for this toxicity.

    What you should do about this interaction:

    If you experience loss of coordination, sluggishness, muscle weakness, or shaking, contact your doctor. Your healthcare professionals (e.g. doctor or pharmacist) may be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


    1.Ghose K. Interaction between lithium and carbamazepine. Br Med J 1980 Apr 26;280(6222):1122.

    2.Lipinski JF, Pope HG Jr. Possible synergistic action between carbamazepine and lithium carbonate in the treatment of three acutely manic patients. Am J Psychiatry 1982 Jul;139(7):948-9.

    3.Keisling R. Carbamazepine and lithium carbonate in the treatment of refractory affective disorders. Arch Gen Psychiatry 1983 Feb;40(2):223.

    4.Moss GR, James CR. Carbamazepine and lithium carbonate synergism in mania. Arch Gen Psychiatry 1983 May;40(5):588-9.

    5.Chaudhry RP, Waters BG. Lithium and carbamazepine interaction: possible neurotoxicity. J Clin Psychiatry 1983 Jan;44(1):30-1.

    6.Post RM, Uhde TW. Carbamazepine and lithium carbonate synergism in mania. Arch Gen Psychiatry 1984 Feb;41(2):210.

    7.Andrus PF. Lithium and carbamazepine. J Clin Psychiatry 1984 Dec; 45(12):525.

    8.Shukla S, Godwin CD, Long LE, Miller MG. Lithium-carbamazepine neurotoxicity and risk factors. Am J Psychiatry 1984 Dec;141(12):1604-6.

    9.Laird LK, Knox EP. The use of carbamazepine and lithium in controlling a case of chronic rapid cycling. Pharmacotherapy 1987;7(4):130-2.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

    More about Drugs and Medications

    URAC Seal TRUSTe Privacy Certification TAG Registered Seal HONcode Seal AdChoices