VALPROIC ACID Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • decreased blood platelets
  • nystagmus, a condition with involuntary eye movements
  • fluid retention in the legs, feet, arms or hands
  • trouble breathing
  • an accidental injury

If experienced, these tend to have a Less Severe expression i

  • an infection
  • depression
  • blurred vision
  • ringing in the ears
  • bruising under the skin
  • throat irritation
  • a stuffy and runny nose
  • bronchitis
  • indigestion
  • constipation
  • irregular periods
  • hair loss
  • drowsiness
  • memory loss
  • dizziness
  • difficulty sleeping
  • fever
  • flu-like symptoms
  • muscle tremors
  • loss of muscle coordination
  • decreased appetite
  • weight gain
  • weight loss
  • increased hunger
  • headache
  • nausea
  • vomiting
  • diarrhea
  • generalized weakness
  • intense abdominal pain

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • mood changes
  • mental status changes

If experienced, these tend to have a Less Severe expression i

  • widening of blood vessels
  • backache
  • taste impairment
  • abnormal manner of walking
  • nervousness
  • reactions at the site of the injection

RARE side effects

If experienced, these tend to have a Severe expression i

  • a disorder with excess antidiuretic hormone called syndrome of inappropriate antidiuretic hormone
  • polycystic ovarian syndrome, a disease with cysts in the ovaries
  • high amount of ammonium in the blood
  • hereditary liver metabolism disorder
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • low blood counts due to bone marrow failure
  • anemia
  • a decrease in platelet clotting
  • very low levels of granulocytes, a type of white blood cell
  • low levels of white blood cells
  • increased eosinophils in the blood
  • increased lymphocyte cells in the blood
  • suicidal thoughts
  • behavioral problems
  • a type of movement disorder called parkinsonism
  • tardive dyskinesia, a disorder characterized by involuntary movements of the face, mouth and tongue
  • a type of brain function problem called encephalopathy
  • hearing loss
  • high blood pressure
  • slow heartbeat
  • inflammation of the middle tissue heart muscle
  • inflammation of blood vessels in the skin
  • acute liver failure
  • inflammation of the liver called hepatitis
  • acute inflammation of the pancreas
  • a type of kidney inflammation called interstitial nephritis
  • kidney inflammation
  • inflammation of the bladder
  • male infertility
  • increased sensitivity of the skin to the sun
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • osteoporosis, a condition of weak bones
  • puffy face from water retention
  • swollen lymph nodes
  • bloody vomit
  • abnormal liver function tests
  • a broken bone
  • low body temperature
  • a significant type of allergic reaction called anaphylaxis
  • a yellowing of the eyes or skin from buildup of bilirubin called jaundice
  • abnormally large red blood cells called macrocytosis
  • high levels of androgen hormones
  • an abnormal sperm size or shape
  • a brain condition called cerebral pseudoatrophy
  • a type of significant allergic skin reaction called DRESS syndrome
  • a paradoxical convulsion

If experienced, these tend to have a Less Severe expression i

  • over excitement
  • agitation
  • aggressive behavior
  • lazy eye
  • a change in vision
  • pink eye
  • inflammation of the tissue lining the sinuses
  • inflammation of the parotid gland
  • dry mouth
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • urinary tract infection
  • enlarged breasts
  • pain with menstruation
  • cessation of menstruation
  • bleeding not related to menstrual period
  • a problem with menstrual periods
  • a nail disorder
  • hirsutism, a condition of hair growth on parts of the body normally without hair
  • hair discoloration
  • seborrhea
  • dry skin
  • an abnormal increase in muscle tone
  • muscle weakness
  • leg cramps
  • bone pain
  • sensation of spinning or whirling
  • a skin rash
  • small reddish-purplish pin-point sized spots on skin
  • nosebleed
  • heart throbbing or pounding
  • cough
  • gas
  • difficult or painful urination
  • involuntary leakage of urine
  • an increased need to urinate often
  • exaggerated deep reflexes
  • a feeling of general discomfort called malaise
  • abnormal dreams
  • a change in the ability to pay attention
  • abnormal hair texture
  • anxious feelings
  • fast heartbeat

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.