PROGRAF Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • low amount of magnesium in the blood
  • high levels of potassium in the blood
  • anemia
  • low levels of white blood cells
  • a blood disorder
  • a toxic effect on the central nervous system, which consists of the brain and spinal cord
  • escape of fluid into the lungs
  • damage to the kidneys
  • hallucinations
  • seizures
  • fluid retention in the legs, feet, arms or hands
  • high blood sugar

If experienced, these tend to have a Less Severe expression i

  • confusion
  • nightmares
  • agitation
  • depression
  • irritation of the stomach or intestines
  • constipation
  • itching
  • dizziness
  • difficulty sleeping
  • muscle tremors
  • a skin rash
  • decreased appetite
  • headache
  • nausea
  • vomiting
  • diarrhea
  • nervousness
  • a feeling of pins and needles on skin
  • generalized weakness
  • intense abdominal pain
  • anxious feelings

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • a hormone disorder where the body produces high levels of cortisol called Cushing's syndrome
  • low amount of potassium in the blood
  • high blood pressure
  • cardiomyopathy, a disease of the heart muscle
  • decreased kidney function
  • osteoporosis, a condition of weak bones
  • trouble breathing
  • chest pain

If experienced, these tend to have a Less Severe expression i

  • high amount of triglyceride in the blood
  • excessive fat in the blood
  • a change in vision
  • ringing in the ears
  • indigestion
  • urinary tract infection
  • cramps
  • excessive sweating
  • pain
  • peripheral sensory nerve disorder

RARE side effects

If experienced, these tend to have a Severe expression i

  • an unusual viral infection called cytomegalovirus infection
  • an infection due to a virus
  • a type of blood disorder where the red blood cells burst called hemolytic anemia
  • hemolytic uremic syndrome, a condition that affects the kidney and the blood
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • a type of blood clotting disorder called disseminated intravascular coagulation
  • low platelet count and bleeding from immune response
  • decreased blood platelets
  • very low levels of granulocytes, a type of white blood cell
  • low levels of a type of white blood cell called neutrophils
  • mental problems from taking the drug
  • myoclonus, quick and involuntary muscle jerks
  • a type of brain function problem called encephalopathy
  • leukoencephalopathy, a disease of the white matter of the brain
  • a disorder of the peripheral nerves that enable movement called peripheral motor neuropathy
  • optic neuropathy, a disease of the optic nerve
  • hearing loss
  • abnormal heart electrical signals
  • torsades de pointes, a type of abnormal heart rhythm
  • slow heartbeat
  • prolonged QT interval on EKG
  • abnormal heart rhythm
  • chronic heart failure
  • left ventricular hypertrophy
  • abnormal bleeding in the brain resulting in damage to brain tissue, called a hemorrhagic stroke
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • a stomach ulcer
  • inflammation of the lining of the stomach and intestines
  • damage to the liver and inflammation
  • kidney failure
  • inflammation of the bladder with hemorrhage
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • an abnormal increase in muscle tone
  • abnormal liver function tests
  • a significant type of allergic reaction called anaphylaxis
  • disorder of lymphoid tissue after transplant
  • malignant lymphoma
  • a rupture in the wall of the stomach or intestine
  • lung tissue problem
  • pancreatitis
  • progressive multifocal leukoencephalopathy, a type of brain infection
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • kidney problems due to BK polyomavirus
  • hemiparesis
  • pure red cell aplasia
  • a high alanine transaminase level
  • a high aspartate transaminase level

If experienced, these tend to have a Less Severe expression i

  • mood changes
  • carpal tunnel syndrome
  • nerve pain
  • leg cramps
  • drowsiness
  • memory loss
  • fainting
  • sensation of spinning or whirling
  • loss of muscle coordination
  • slurred speech
  • a condition where there is excess sugar in the urine
  • impaired wound healing
  • problems thinking clearly
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.