Artemether; Lumefantrine/Antimalarials Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Antimalarials can affect your heart's rhythm

What might happen:

The rhythm of your heart may change and this may be life-threatening.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) right away about taking these medicines together. Your doctor may want to change your medicine. Let your doctor know if you have recently taken other antimalarial agents such as halofantrine or quinine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Giao PT, de Vries PJ. Pharmacokinetic interactions of antimalarial agents. Clin Pharmacokinet 2001;40(5):343-73.
  • 2.Coartem (artemether/lumefantrine) US prescribing information. Novartis Pharmaceuticals Corporation August, 2019.
  • 3.Riamet (artemether/lumefantrine) UK summary of product characteristics. Novartis Pharmaceuticals UK Ltd. June 27, 2001.
  • 4.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
  • 5.Lefevre G, Bindschedler M, Ezzet F, Schaeffer N, Meyer I, Thomsen MS. Pharmacokinetic interaction trial between co-artemether and mefloquine. Eur J Pharm Sci 2000 Apr;10(2):141-51.
  • 6.van Agtmael MA, Van Der Graaf CA, Dien TK, Koopmans RP, van Boxtel CJ. The contribution of the enzymes CYP2D6 and CYP2C19 in the demethylation of artemether in healthy subjects. Eur J Drug Metab Pharmacokinet 1998 Jul-Sep;23(3):429-36.
  • 7.Tan-ariya P, Na-Bangchang K, Ubalee R, Thanavibul A, Thipawangkosol P, Karbwang J. Pharmacokinetic interactions of artemether and pyrimethamine in healthy male Thais. Southeast Asian J Trop Med Public Health 1998 Mar; 29(1):18-23.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.