This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Amiodarone may slow down how quickly your liver processes your fentanyl.
What might happen:
The amount of fentanyl in your blood may increase and cause more side effects than expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to adjust the dose of your fentanyl or monitor its effects more closely.If you have unusually slow or shallow breathing, get help right away. If you feel more sleepy or tired than normal, contact your healthcare professional as soon as possible.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
- 2.Duragesic (fentanyl) US prescribing information. Janssen Pharmaceuticals, Inc. October, 2019.
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- 6.MacKinnon G, Landymore R, Marble A. Should oral amiodarone be used for sustained ventricular tachycardia in patients requiring open-heart surgery?. Can J Surg 1983 Jul;26(4):355-7.
- 7.Navalgund AA, Alifimoff JK, Jakymec AJ, Bleyaert AL. Amiodarone-induced sinus arrest successfully treated with ephedrine and isoproterenol. Anesth Analg 1986 Apr;65(4):414-6.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.