Doxycycline/CYP3A4 Inducers Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process doxycycline properly.

What might happen:

Your blood levels of doxycycline may decrease and reduce the ability of the medicine to treat your infection.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Your doctor may need to adjust the dose of your antibiotic or change your medicine to another antibiotic. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Penttila O, Neuvonen PJ, Aho K, Lehtovaara R. Interaction between doxycycline and some antiepileptic drugs. Br Med J 1974 Jun 1; 2(917):470-2.
  • 2.Neuvonen PJ, Penttila O. Interaction between doxycycline and barbiturates. Br Med J 1974 Mar 23;1(907):535-6.
  • 3.Neuvonen PJ, Penttila O, Lehtovaara R, Aho K. Effect of antiepileptic drugs on the elimination of various tetracycline derivatives. Eur J Clin Pharmacol 1975 Dec 19;9(2-3):147-54.
  • 4.Garraffo R, Dellamonica P, Fournier JP, Lapalus P, Bernard E, Beziau H, Chichmanian RM. Effects of rifampicin on the pharmacodynamics of doxycycline. Pathol Biol (Paris) 1987 Jun;35(5 Pt 2):746-9.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.