VORICONAZOLE Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • a change in vision
  • fever
  • high amount of bilirubin in the blood
  • abnormal liver function tests
  • fast heartbeat
  • a high alanine transaminase level
  • a high aspartate transaminase level

If experienced, these tend to have a Less Severe expression i

  • chills
  • nausea
  • vomiting

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • low amount of magnesium in the blood
  • low amount of calcium in the blood
  • low amount of potassium in the blood
  • high blood pressure
  • low blood pressure
  • widening of blood vessels
  • a blockage of the bile duct that resulting in high bilirubin levels
  • fluid retention in the legs, feet, arms or hands
  • chest pain

If experienced, these tend to have a Less Severe expression i

  • visual sensitivity to light
  • acquired chromatopsia, a change in color vision
  • optic disk edema
  • dry mouth
  • inflammation of the lips
  • headache
  • diarrhea
  • intense abdominal pain
  • a type of bumpy skin rash called a maculopapular rash

RARE side effects

If experienced, these tend to have a Severe expression i

  • diarrhea from an infection with Clostridium difficile bacteria
  • a systemic inflammatory response called sepsis due to an infection with bacteria
  • malignant melanoma, a type of skin cancer
  • squamous cell carcinoma
  • overactive thyroid gland
  • a condition with low thyroid hormone levels
  • diabetes insipidus
  • decreased function of the adrenal gland
  • osteomalacia, or softening of bones
  • a type of blood disorder where the red blood cells burst called hemolytic anemia
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • low blood counts due to bone marrow failure
  • anemia
  • a type of blood clotting disorder called disseminated intravascular coagulation
  • decreased blood platelets
  • very low levels of granulocytes, a type of white blood cell
  • low levels of white blood cells
  • suicidal thoughts
  • extrapyramidal disease, a type of movement disorder
  • bleeding from the retina
  • changes in the visual field
  • corneal opacity, a scarring disorder that results in clouding of the cornea of the eye
  • sudden blindness and pain upon moving the eye
  • bleeding in the eye
  • complete heart block
  • bundle branch block
  • torsades de pointes, a type of abnormal heart rhythm
  • slow heartbeat
  • prolonged QT interval on EKG
  • ventricular arrhythmias, a type of abnormal heart rhythm
  • an enlarged heart
  • a stroke
  • cerebral ischemia, a lack of blood supply to the brain
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • acute respiratory distress syndrome, a type of lung disorder
  • bleeding gums
  • inflammation of the esophagus
  • an ulcer in the esophagus
  • inflammation of the lining of the stomach and intestines
  • blood coming from anus
  • acute liver failure
  • liver failure
  • inflammation of the liver called hepatitis
  • blockage of normal bile flow
  • acute inflammation of the pancreas
  • bleeding of the stomach or intestines
  • a type of kidney inflammation called interstitial nephritis
  • renal tubular necrosis, a kidney disorder
  • kidney failure
  • inflammation of the bladder with hemorrhage
  • bloody urine
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • subacute cutaneous lupus erythematosus
  • psoriasis
  • osteoporosis, a condition of weak bones
  • seizures
  • swelling of the tongue
  • bloody vomit
  • an inability to completely empty the bladder
  • decreased urine production
  • ascites
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • high pressure within the skull
  • a rupture in the wall of the stomach or intestine
  • a yellowing of the eyes or skin from buildup of bilirubin called jaundice
  • cessation of urine production
  • multiple organ failure
  • atrial arrhythmia, a type or abnormal heart beat
  • fluoride deposits in bone
  • periostitis, or inflammation of connective tissue around bones
  • a type of significant allergic skin reaction called DRESS syndrome

If experienced, these tend to have a Less Severe expression i

  • confusion
  • agitation
  • depression
  • pink eye
  • inflammation of the eyelid
  • ringing in the ears
  • stuffy nose
  • inflammation of the gums
  • a painful, red or swollen tongue
  • indigestion
  • constipation
  • urinary tract infection
  • the inability to have an erection
  • pain with menstruation
  • bleeding not related to menstrual period
  • skin inflammation
  • increased sensitivity of the skin to the sun
  • hair loss
  • joint pain
  • backache
  • muscle pain
  • leg cramps
  • delirium
  • dizziness
  • difficulty sleeping
  • loss of muscle coordination
  • puffy face from water retention
  • temporary redness of face and neck
  • decreased appetite
  • a change in voice
  • rapid breathing
  • difficulty swallowing
  • gas
  • difficult or painful urination
  • involuntary leakage of urine
  • a feeling of pins and needles on skin
  • pain in the upper abdomen or back and sides
  • generalized weakness
  • chest pains unrelated to heart problems
  • a sun sensitivity reaction with skin blisters called pseudoporphyria
  • inflammation of the vein, or phlebitis after infusion

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.