If you are:
Possibly Safe: INSUFFICIENT HUMAN DATA AVAILABLE
Only When Necessary: CROSSES HUMAN PLACENTA & FOUND IN FETAL TISSUE;MANUFACT. RECOMMENDS NOT USING.
Precaution: NO KNOWN INFANT ADVERSE OUTCOMES; MFR ADVISES CAUTION
Precaution: INSUFFICIENT HUMAN DATA AVAILABLE; ANIMAL DATA SUGGEST EXCRETION
An adult over 60:
management or monitoring precaution: Renal-Increased risk for drug induced metabolic acidosis with increasing age and declining renal function. Metformin is contraindicated in patients with an eGFR below 30 mL/min. Cardiovascular-Heart failure patients may have a higher risk for metabolic acidosis.
management or monitoring precaution: Cardiovascular-Box warning states drug may cause or exacerbate CHF. Contraindicated in patients with NYHA Class III or IV heart failure. Monitor for weight gain, peripheral edema and new onset dyspnea. Hepatic-Monitor for elevations of serum transaminases. Musculoskeletal-Consider increased fracture risk.
Giving Avandamet to a child under 12:
management or monitoring precaution: Safety and efficacy in pediatrics age < 10 years not established.
management or monitoring precaution: Insufficient efficacy data to support pediatric use. Pediatric studies demonstrated less effect in lowering fasting glucose from baseline when compared to metformin.