What should I Know Regarding Pregnancy, Nursing and Administering Valproic Acid Liquid to Children or the Elderly?

If you are PREGNANT

  • Not Recommended: INCR RISK OF NEURAL TUBE DEFECTS AND LOWER IQ, CONSIDER MATERNAL TX BENEFIT

If you are NURSING

  • Precaution: LIMITED DATA SUGGEST MINIMAL AMNT EXCRETED;MONITOR INFANT FOR ADVERSE EFFECTS

If you are an adult over 60

Giving Valproic Acid Liquid to a child under 12

  • management or monitoring precaution: Fatal hepatotoxicity risk in young children with mitochondrial disease associated with POLG gene mutation and on multiple anticonvulsants. Monitor closely for liver impairment including non-specific symptoms (e.g., lethargy, facial edema,vomiting. Rare risk of severe pancreatitis.
  • Severe Precaution: Risk of serious or fatal hepatotoxicity in age <2 years especially with multiple anticonvulsants, and mitochondrial disease associated with POLG gene mutation. Use as single agent and monitor closely for liver impairment, including non-specific symptoms (e.g., lethargy, facial edema,vomiting).

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.