This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of your medicines can cause dehydration and kidney problems.
What might happen:
You may develop dehydration and kidney problems.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together, if you have any trouble with your kidneys, and if you are on a low salt diet. If you experience signs of dehydration such as dizziness, fainting, lightheadedness, weakness, (especially when you stand up) or kidney damage such as decreased urine production or swelling in the hands/feet, contact your doctor.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Wolf MS. Personal communication: Invokana - Concomitant use with diuretics. Janssen Scientific Affairs, LLC June 9, 2014.
2.Invokana (canagliflozin) US prescribing information. Janssen Pharmaceuticals, Inc. May, 2016.
3.Farxiga (dapagliflozin) US prescribing information. AstraZeneca Pharmaceuticals LP June, 2016.
4.USFood and Drug Administration. FDA Drug Safety Communication: FDA strengthens kidney warnings for diabetes medicines canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR). available at: http://www.fda.gov/downloads/Drugs/DrugSafety/UCM506772.pdf June 14, 2016.