Edoxaban/Antiplatelets; Aspirin (> 100 mg) Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

All of these medicines can affect your blood's ability to clot.

What might happen:

Taking these medicines together or within a short time of each other may increase your risk of bleeding, including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Let your doctor know right away if you have any bleeding episodes or signs of bleeding.If your doctor is changing you from one anticoagulant to another, be sure to follow any special instructions you receive about this change.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Savaysa (edoxaban) US prescribing information. Daiichi Sankyo, Inc September, 2016.
  • 2.Lixiana (edoxaban tosilate) UK summary of product characteristics. Daiichi Sankyo UK Limited July 2, 2015.
  • 3.Lixiana (edoxaban) Canadian product monograph. Servier Canada Inc. January 12, 2017.
  • 4.FDA Center for Drug Evaluation and Research (CDER). Application number 206316 Savaysa (edoxaban tosylate) Clinical Pharmacology and Biopharmaceutics Review. available at: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/206316Orig1Orig2s00 0ClinPharmR.pdf January 8, 2015.