Selected Anticoagulants (Vit K antagonists)/Disulfiram Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Disulfiram can slow down how quickly your body processes your anticoagulant (e.g. warfarin).

What might happen:

You may experience an increased chance for bleeding.

What you should do about this interaction:

Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it.If your doctor prescribes these two medicines together, you may need to check your bleeding times more often. Your anticoagulant dosage may need to be adjusted while you are taking disulfiram. Contact your healthcare provider as soon as possible if have unusual bleeding from the gums or nose; unusual bruising; red or black, tarry stools; red, pink or dark brown urine; sudden severe abdominal or joint pain and/or swelling.Do not start, stop, or change the dosage of any medicine before checking with your healthcare professional first.

  • 1.Rothstein E. Warfarin effect enhanced by disulfiram. JAMA 1968 Nov 11; 206(7):1574-5.
  • 2.O'Reilly RA. Potentiation of anticoagulant effect by disulfiram (Antabuse). Clin Res 1971;19(1):180.
  • 3.O'Reilly RA. Augmentation of long-term warfarin therapy by disulfiram (Antabuse). Clin Res 1972;20(2):185.
  • 4.Rothstein E. Warfarin effect enhanced by disulfiram (antabuse). JAMA 1972 Aug 28;221(9):1052-3.
  • 5.O'Reilly RA. Interaction of sodium warfarin and disulfiram (antabuse) in man. Ann Intern Med 1973 Jan;78(1):73-6.
  • 6.O'Reilly RA. Dynamic interaction between disulfiram and separated enantiomorphs of racemic warfarin. Clin Pharmacol Ther 1981 Mar; 29(3):332-6.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.