Delavirdine; Etravirine/Selected Anticonvulsants Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Certain anticonvulsants may speed up how quickly your liver processes delavirdine or etravirine.

What might happen:

Your blood levels of delavirdine or etravirine may decrease. If the amount of medicine decreases too much, it may not be effective against your HIV infection and your HIV infection may develop resistance to these and other non-nucleoside reverse transcriptase inhibitors (NNRTI's).

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Rescriptor (delavirdine mesylate) US prescribing information. Pharmacia & Upjohn Company August, 2012.
  • 2.Intelence (etravirine) US prescribing information. Janssen Pharmaceuticals August, 2014.