Hydroxyzine/Possible QT Prolonging Agents Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Hydroxyzine may affect your heart's rhythm. Other drugs can have the same effect.

What might happen:

Taking hydroxyzine with agents that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening.

What you should do about this interaction:

Let your healthcare professionals (e.g doctor or pharmacist) know right away that you are taking these medications together. Let your doctor know right away if you notice an irregular heartbeat or have dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Health Canada. Summary Safety Review - Hydroxyzine (ATARAX and generics) - Assessing the Potential Risk of Abnormal Heart Rhythm. availalble at: http://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/atarax-eng.php June 6, 2016.
  • 2.Atarax (hydroxyzine hydrochloride) Canadian product monograph. Erfa May 10, 2016.
  • 3.Atarax (hydroxyzine hydrochloride) UK summary of product characteristics. Alliance Pharmaceuticals Limited October, 2015.
  • 4.Vistaril (hydroxyzine pamoate) US prescribing information. Pfizer November 8, 2016.
  • 5.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
  • 6.European Medicines Agency (EMA) Pharmacovigilance Risk Assessment Committee (PRAC). Hydroxyzine-containing medicinal products. available at: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Hy droxyzine_31/Position_provided_by_CMDh/WC500185947.pdf February 12, 2015.
  • 7.Woosley RL, Romero KA. www.Crediblemeds.org, QTdrugs List, AZCERT, Inc. 1822 Innovation Park Dr., Oro Valley, AZ 85755. November 17, 2015.