What should I Know Regarding Pregnancy, Nursing and Administering Paroxetine HCl to Children or the Elderly?

If you are pregnant

  • Not Recommended:
  • If you are nursing

  • If you are an adult over 60

  • management or monitoring precaution: General-Anticholinergic side effects may be seen at higher doses. Dosing-Initial dose should be reduced since elderly have minimum plasma concentrations (Cmin) that are 70-80% greater than younger adults. Endocrine-Elderly are at higher risk for hyponatremia due to SIADH from SSRIs. Renal-CrCl of 30-60 mL/min resulted in 2-fold higher plasma concentrations. Hepatic-Hepatic impairment increases plasma concentrations.
  • Pediatric use

  • Severe Precaution: Possible increased risk of suicide, emotional lability, behavioral changes, hyperkinesia in pediatric and adolescent patients. May decrease appetite; monitor growth rate. No efficacy data for treating depression.
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    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.