Thioridazine/Selected SSRIs; Duloxetine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some selective serotonin reuptake inhibitors and duloxetine may slow down how quickly your liver processes thioridazine.
What might happen:
The level of thioridazine in your blood may increase. This may increase your risk of an irregular heartbeat, which may be life-threatening.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) right away about takings these medicines together. Let your doctor know right away if you notice an irregular heartbeat or have dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Priligy (dapoxetine hydrochloride) Australian prescribing information. Ortho-McNeil Pharmaceutical March 19, 2013.
- 2.Cymbalta (duloxetine hydrochloride) US prescribing information. Eli Lilly and Company April, 2020.
- 3.Dear Doctor Letter. Re: Important drug warning about Mellarill. Novartis Pharmaceuticals Corporation July 7, 2000.
- 4.Thioridazine tablet, US prescribing information. Mutual Pharmaceutical September, 2014.
- 5.Sarafem (fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company January, 2017.
- 6.Prozac (fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company October, 2014.
- 7.Symbyax (olanzapine and fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company April, 2020.
- 8.Luvox (fluvoxamine maleate) US prescribing information. Jazz Pharmaceuticals, Inc. January, 2017.
- 9.Paxil (paroxetine hydrochloride) US prescribing information. Apotex Technologies January, 2017.
- 10.Pexeva (paroxetine mesylate) US prescribing information. Noven Therapeutics, LLC December, 2012.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.