VELCADE Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • shingles
  • dehydration
  • low amount of potassium in the blood
  • anemia
  • decreased blood platelets
  • low levels of a type of white blood cell called neutrophils
  • low blood pressure
  • a common cold
  • pneumonia
  • fluid retention in the legs, feet, arms or hands
  • trouble breathing
  • a feeling of pins and needles on skin
  • abnormal sensations of the skin

If experienced, these tend to have a Less Severe expression i

  • low levels of white blood cells
  • a decreased number of lymphocytes in the blood
  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
  • blurred vision
  • throat irritation
  • indigestion
  • constipation
  • itching
  • joint pain
  • backache
  • muscle pain
  • nerve pain
  • pain in the arms or legs
  • cramps
  • bone pain
  • dizziness
  • difficulty sleeping
  • low energy
  • chills
  • taste impairment
  • a skin rash
  • visible water retention
  • decreased appetite
  • headache
  • cough
  • nausea
  • vomiting
  • diarrhea
  • generalized weakness
  • intense abdominal pain
  • anxious feelings

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • mental problems
  • chronic heart failure
  • a hole in the intestine

If experienced, these tend to have a Less Severe expression i

  • a herpes simplex infection
  • high blood sugar

RARE side effects

If experienced, these tend to have a Severe expression i

  • a systemic inflammatory response called sepsis due to an infection with bacteria
  • nerve pain after herpes
  • a shingles outbreak that involves the eye
  • low amount of calcium in the blood
  • high amount of calcium in the blood
  • an increased sodium level in the blood
  • low amount of sodium in the blood
  • high levels of potassium in the blood
  • hemolytic uremic syndrome, a condition that affects the kidney and the blood
  • a type of blood clotting disorder called disseminated intravascular coagulation
  • suicidal thoughts
  • paralysis
  • a type of brain function problem called encephalopathy
  • a sudden loss of vision
  • double vision
  • vision loss
  • optic neuropathy, a disease of the optic nerve
  • hearing loss
  • high blood pressure
  • a heart attack
  • angina, a type of chest pain
  • a low supply of oxygen rich blood to the heart
  • a clot in the lung
  • pulmonary hypertension
  • inflammation of the covering of the heart or pericardium
  • pericardial tamponade, a disorder of the heart
  • fluid in the covering of the heart or pericardium
  • atrioventricular block, a type of slow heart rhythm disorder
  • sinus arrest, a type of heart condition
  • rapid ventricular heartbeat
  • torsades de pointes, a type of abnormal heart rhythm
  • atrial fibrillation
  • atrial flutter
  • slow heartbeat
  • prolonged QT interval on EKG
  • a hemorrhage in the brain
  • abnormal bleeding in the brain resulting in damage to brain tissue, called a hemorrhagic stroke
  • a transient ischemic attack, a type of stroke that lasts only a few minutes
  • a stroke
  • allergic reaction causing inflammation of blood vessels
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • blood clot formation in vein
  • vocal cord swelling
  • escape of fluid into the lungs
  • a type of inflammation of the lung called interstitial pneumonitis
  • a complete or partial collapse of the lung airways called atelectasis
  • x-ray results showing lung tissue changes
  • acute respiratory distress syndrome, a type of lung disorder
  • a type of stomach irritation called gastritis
  • insufficient blood supply to the colon
  • inflammation of the lining of the stomach and intestines
  • paralysis of the intestines
  • blocked bowels with decreased peristaltic movement
  • a blockage of the intestines with stool
  • blockage of the stomach or intestine
  • inflammation and infection of the abdomen lining
  • acute liver failure
  • inflammation of the liver called hepatitis
  • blockage of normal bile flow
  • acute inflammation of the pancreas
  • glomerulonephritis, a condition that affects the kidneys
  • kidney failure
  • kidney stones
  • inflammation of the bladder with hemorrhage
  • bloody urine
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • Sweet's disease
  • coma
  • mental status changes
  • seizures
  • high amount of bilirubin in the blood
  • coughing up of blood
  • bloody vomit
  • ascites
  • high amount of uric acid in the blood
  • bacteria in the blood
  • decreased oxygen in the tissues or blood
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • a hypersensitivity reaction to a drug
  • progressive multifocal leukoencephalopathy, a type of brain infection
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • worsening of chronic heart failure
  • worsening chronic obstructive pulmonary disease
  • herpes simplex meningitis

If experienced, these tend to have a Less Severe expression i

  • an infection due to a virus
  • thrush
  • inflammation of the eyelid
  • eye irritation
  • inflammation of the tissue lining the sinuses
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • gastroesophageal reflux disease
  • black tarry stools
  • hives
  • sensation of spinning or whirling
  • loss of muscle coordination
  • puffy face from water retention
  • difficulty swallowing
  • an inability to completely empty the bladder
  • involuntary leakage of urine
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.