Selected Chelation Agents/Aluminum Salts Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, antacids may prevent your body from absorbing deferasirox and penicillamine properly.

What might happen:

The beneficial effects of deferasirox and penicillamine may decrease.

What you should do about this interaction:

Separate the times you take your deferasirox or penicillamine and your antacid by as much time as possible and by at lease two hours.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Osman MA, Patel RB, Schuna A, Sundstrom WR, Welling PG. Reduction in oral penicillamine absorption by food, antacid, and ferrous sulfate. Clin Pharmacol Ther 1983 Apr;33(4):465-70.
  • 2.Exjade (deferasirox) US prescribing information. Novartis Pharmaceuticals Corporation July, 2015.