Entacapone; Tolcapone/Selected MAOIs Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not be able to process certain body chemicals (e.g. epinephrine) properly.

What might happen:

You may experience a faster heart rate and/or an increase in blood pressure.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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  • 2.Tasmar (tolcapone) US prescribing information. Valeant Pharmaceuticals International May, 2013.
  • 3.Comtan (entacapone) US prescribing information. Orion Corporation June, 2014.
  • 4.Comtan (entacapone) Canadian prescribing information. Novartis Pharmaceuticals Canada Inc. March, 2006.
  • 5.Tasmar (tolcapone) UK summary of product characteristics. Valeant Pharmaceuticals Ltd. Januar 11, 2006.
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