Dolutegravir/Selected Oral Cations Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your medicine contains aluminum, calcium, iron, lanthanum, magnesium, and/or sucralfate, which are cations that may bind to your dolutegravir in your digestive tract. This prevents your body from absorbing dolutegravir.

What might happen:

The blood levels of your dolutegravir may be decreased, which will decrease its effectiveness.

What you should do about this interaction:

You should time when you take your dolutegravir and your other medicine so that you do take dolutegravir either 2 hours before or 6 hours after your other medicine. If you have questions about how to time when you take your medicines, ask your pharmacist.

  • 1.Tivicay (dolutegravir) US prescribing information. GlaxoSmithKline June, 2016..