Eltrombopag/Polyvalent Cations Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Medicines containing aluminum, calcium, iron, magnesium, selenium, and zinc may bind to eltrombopag in your digestive tract.

What might happen:

Your body may not absorb as much eltrombopag and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Time your medicines so that you do not take your eltrombopag two hours before or four hours after any medicine containing aluminum, calcium, iron, magnesium, selenium, or zinc.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Promacta (eltrombopag) US prescribing information. GlaxoSmithKline October, 2016.
  • 2.Williams DD, Peng B, Bailey CK, Wire MB, Deng Y, Park JW, Collins DA, Kapsi SG, Jenkins JM. Effects of food and antacids on the pharmacokinetics of eltrombopag in healthy adult subjects: two single-dose, open-label, randomized-sequence, crossover studies. Clin Ther 2009 Apr;31(4):764-76.