What should I Know Regarding Pregnancy, Nursing and Administering Lansoprazole-Naproxen Combination Package to Children or the Elderly?
If you are PREGNANT
- Requires a Risk/Benefit Assessment:
If you are NURSING
- Precaution: INSUFFICIENT HUMAN DATA AVAIL; LOW MW, EXCRETION POSSIBLE
- Precaution: INSUFFICIENT DATA AVAILABLE; LOW LEVELS FOUND IN BREASTMILK
If you are an adult over 60
- management or monitoring precaution: General-Prolonged use may decrease absorption of Vitamin B-12. Avoid for >8 weeks duration unless for high risk patients (eg. oral corticosteroids or chronic NSAID use), erosive esophagitis, Barrett's esophagitis, pathologic hypersecretory condition, or demonstrated need for maintenance treatment. Musculoskeletal-Increased risk of fracture with high dose or prolonged use of greater than 1 year. Gastrointestinal-Long term use may be associated with C. difficile diarrhea.
- management or monitoring precaution: Gastrointestinal-Risk for ulceration or serious GI bleed; highest with history of PUD or GI bleed. Renal-Risk for exacerbation of CKD. Cardiovascular-May exacerbate pre-existing hypertension or CHF. Risk of cardiovascular thrombotic events, including MI and stroke. This risk may occur early in treatment and increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated with CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.
Giving Lansoprazole-Naproxen Combination Package to a child under 12
- management or monitoring precaution: Adhere to recommended dose and duration of therapy. Unknown safety and efficacy for long term treatment.
- Severe Precaution: Risk of heart valve thickening and bone changes based on animal studies. Efficacy not established in pediatric trials for symptomatic GERD age <1 year.
- management or monitoring precaution: Safety and efficacy not established in children age less than 2 years.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.