Hydroxyurea Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • low levels of white blood cells
  • low levels of a type of white blood cell called neutrophils
  • If experienced, these tend to have a Less Severe expression i

  • drowsiness
  • decreased appetite
  • headache
  • nausea
  • vomiting
  • diarrhea
  • INFREQUENT side effects

    If experienced, these tend to have a Severe expression i

  • anemia
  • decreased blood platelets
  • x-ray results showing lung tissue changes
  • If experienced, these tend to have a Less Severe expression i

  • constipation
  • erythema or redness of skin or mucous membrane
  • itching
  • hair loss
  • dry skin
  • a skin rash
  • RARE side effects

    If experienced, these tend to have a Severe expression i

  • increased uric acid in the body resulting in kidney disease
  • a type of blood disorder where the red blood cells burst called hemolytic anemia
  • a toxic effect on the central nervous system, which consists of the brain and spinal cord
  • inflammation of blood vessels in the skin
  • a type of inflammation of the lung called interstitial pneumonitis
  • a condition where there is formation of fibrous tissue in the lung called pulmonary fibrosis
  • inflammation of the alveoli of the lungs
  • liver failure
  • inflammation of the liver called hepatitis
  • blockage of normal bile flow
  • decreased kidney function
  • a skin ulcer
  • systemic lupus erythematosus, an autoimmune disease
  • inflammation of the skin and muscle
  • hallucinations
  • seizures
  • a tonic-clonic seizure
  • abnormal liver function tests
  • basal cell carcinoma of the skin
  • a type of bumpy skin rash called a maculopapular rash
  • pancreatitis
  • skin cancer
  • therapy-related acute myeloid leukemia
  • abnormally large red blood cells called macrocytosis
  • radiation recall syndrome
  • cancer of the squamous cells in the skin
  • tumor lysis syndrome
  • If experienced, these tend to have a Less Severe expression i

  • a type of stomach irritation called gastritis
  • low sperm count
  • absence of menstrual periods
  • thin fragile skin
  • a nail disorder
  • darkening of the skin
  • dizziness
  • chills
  • visible water retention
  • scaling of the skin
  • weight gain
  • difficult or painful urination
  • generalized weakness
  • a feeling of general discomfort called malaise
  • absence of sperm in semen
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.