Who should not take Symbyax?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:

Conditions:

  • diabetes
  • a disorder with excess antidiuretic hormone called syndrome of inappropriate antidiuretic hormone
  • low amount of sodium in the blood
  • an increased risk of bleeding
  • manic behavior
  • a form of mania that has a lower severity of symptoms
  • manic-depression
  • suicidal thoughts
  • serotonin syndrome
  • a type of disorder with high serotonin levels
  • closed angle glaucoma
  • heart attack within the last 30 days
  • torsades de pointes
  • a type of abnormal heart rhythm
  • prolonged QT interval on EKG
  • suddenly serious symptoms of heart failure
  • abnormal EKG with QT changes from birth
  • hardening of the liver
  • liver problems
  • bleeding from stomach
  • esophagus or duodenum
  • seizures
  • decreased appetite
  • CYP2D6 poor metabolizer
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye
  • breast cancer
  • a high prolactin level
  • high cholesterol
  • high amount of triglyceride in the blood
  • excessive fat in the blood
  • dehydration
  • overweight
  • low levels of white blood cells
  • low levels of a type of white blood cell called neutrophils
  • a type of movement disorder called parkinsonism
  • tardive dyskinesia
  • a disorder characterized by involuntary movements of the face
  • mouth and tongue
  • neuroleptic malignant syndrome
  • a reaction characterized by fever
  • muscle rigidity and confusion
  • a low seizure threshold
  • a heart attack
  • a low supply of oxygen rich blood to the heart
  • slow heartbeat
  • sinus tachycardia
  • a type of fast heart rate
  • abnormal heart rhythm
  • chronic heart failure
  • a transient ischemic attack
  • a type of stroke that lasts only a few minutes
  • a stroke
  • a disorder of the blood vessels of the brain
  • orthostatic hypotension
  • a form of low blood pressure
  • low blood pressure
  • paralysis of the intestines
  • severe liver disease
  • enlarged prostate with urination problem
  • weight gain
  • abnormal liver function tests
  • susceptible to breathing fluid into lungs
  • decreased blood volume
  • problems with food passing through the esophagus
  • tobacco smoking
  • dementia in an elderly person

Allergies:

  • SSRI's
  • Fluoxetine Analogues
  • Olanzapine

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.