Who should not take Symbyax?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:

Conditions:

  • diabetes
  • syndrome of inappropriate antidiuretic hormone secretion
  • low amount of sodium in the blood
  • increased risk of bleeding
  • behaving with excessive cheerfulness and activity
  • mild degree of mania
  • Manic-Depression
  • having thoughts of suicide
  • serotonin syndrome - adverse drug interaction
  • closed angle glaucoma
  • heart attack within the last 30 days
  • very rapid heartbeat - torsades de pointes
  • prolonged QT interval on EKG
  • suddenly serious symptoms of heart failure
  • abnormal EKG with QT changes from birth
  • hardening of the liver
  • liver problems
  • bleeding from stomach
  • esophagus or duodenum
  • seizures
  • Loss of Appetite
  • CYP2D6 poor metabolizer
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye
  • breast cancer
  • increased prolactin in the blood
  • high cholesterol
  • high amount of triglyceride in the blood
  • excessive fat in the blood
  • extreme loss of body water
  • overweight
  • decreased white blood cells
  • decreased neutrophils a type of white blood cell
  • parkinson symptoms
  • abnormal movements of face
  • muscles
  • and tongue
  • neuroleptic malignant syndrome
  • lower seizure threshold
  • heart attack
  • disease of inadequate blood flow to the heart muscle
  • slow heartbeat
  • sinus tachycardia
  • abnormal heart rhythm
  • chronic heart failure
  • transient ischemic attack
  • stroke
  • disorder of the blood vessels of the brain
  • blood pressure drop upon standing
  • abnormally low blood pressure
  • paralysis of the intestines
  • severe liver disease
  • enlarged prostate with urination problem
  • weight gain
  • abnormal liver function tests
  • Susceptible to Breathing Fluid Into Lungs
  • decreased blood volume
  • Problems with Food Passing Through the Esophagus
  • tobacco smoking
  • Dementia in an Elderly Person

Allergies:

  • SSRI's
  • Fluoxetine Analogues
  • Olanzapine

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.