Ambrisentan (> 5 mg)/Cyclosporine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Cyclosporine may slow down how quickly your body processes ambrisentan.
What might happen:
The amount of ambrisentan in your blood may increase and cause more side effects than expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your medicine if you are taking more than 5 mg of ambrisentan daily. Let your doctor know if have any loss of appetite, nausea/vomiting, fever, unusual tiredness, abdominal pain, yellowing of the skin or whites of your eyes, dark urine, itching, unusual weight gain, trouble breathing, or swelling of the arms or legs.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Letairis (ambrisentran) US prescribing information. Gilead Sciences, Inc. November, 2018.
- 2.Spence R, Mandagere A, Richards DB, Magee MH, Dufton C, Boinpally R. Potential for pharmacokinetic interactions between ambrisentan and cyclosporine. Clin Pharmacol Ther 2010 Oct;88(4):513-20.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.