Maraviroc/Selected Protease Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some protease inhibitors may slow down how quickly your liver processes maraviroc.

What might happen:

The amount of maraviroc in your blood may increase and may cause more side effects than normal.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your medicine. Stop taking maraviroc and call your doctor right away if you develop yellow eyes or skin, dark urine, vomiting, or abdominal pain. Let your doctor know right away if you develop nausea, fever, flu-like symptoms, or fatigue, but continue taking your maraviroc. Let your doctor know if you have any kidney or liver problems, which may make the interaction more severe.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Selzentry (maraviroc) US prescribing information. Pfizer Inc. November, 2016.
  • 2.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories June 15, 2017.
  • 3.Norvir (ritonavir) US prescribing information. Abbott Laboratories June 29, 2017.