Perampanel/Strong and Moderate CYP3A4 Inducers Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your medicine may increase how quickly your liver processes perampanel.

What might happen:

The amount of seizure medicine in your blood may decrease. It may not prevent seizures as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check the amount of seizure medicine in your blood. Your doctor may change the dose of your seizure medicine when you start and/or stop taking your other medicine. If you have any seizures, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Fycompa (perampanel) US prescribing information. Eisai Inc. May, 2019. 2.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2019..
  • 2.Yamamoto Y, Usui N, Nishida T, Takahashi Y, Imai K, Kagawa Y, Inoue Y. Therapeutic Drug Monitoring for Perampanel in Japanese Epilepsy Patients: Influence of Concomitant Antiepileptic Drugs. Ther Drug Monit 2017 Aug; 39(4):446-449.
  • 3.Fycompa (perampanel) UK summary of product characteristics. Eisai Ltd May, 2017.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.