Skip to content

    Zolpidem Spray, Non-Aerosol


    Selected Sedative Hypnotics; Buspirone/Rifampin

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    Rifampin may speed up how quickly your body processes your medicine.

    What might happen:

    Your medicine may not work as well while you are taking rifampin.

    What you should do about this interaction:

    Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have taken rifampin in the previous two weeks. If your medicine does not seem to be working, let your doctor know. Your doctor may want to change the dose of your hypnotic while you are taking rifampin.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


    1.Lamberg TS, Kivisto KT, Neuvonen PJ. Concentrations and effects of buspirone are considerably reduced by rifampicin. Br J Clin Pharmacol 1998 Apr;45(4):381-5.

    2.Kivisto KT, Lamberg TS, Neuvonen PJ. Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone. Pharmacol Toxicol 1999 Feb;84(2):94-7.

    3.Lunesta (eszopiclone) US prescribing information. Sunovion Pharmaceuticals Inc. May, 2014.

    4.Villikka K, Kivisto KT, Lamberg TS, Kantola T, Neuvonen PJ. Concentrations and effects of zopiclone are greatly reduced by rifampicin. Br J Clin Pharmacol 1997 May;43(5):471-4.

    5.Villikka K, Kivisto KT, Luurila H, Neuvonen PJ. Rifampin reduces plasma concentrations and effects of zolpidem. Clin Pharmacol Ther 1997 Dec; 62(6):629-34.

    6.Ambien CR (zolpidem tartrate) US prescribing information. Sanofi-Aventis U.S. LLC April, 2013.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

    More about Drugs and Medications

    URAC Seal TRUSTe Privacy Certification TAG Registered Seal HONcode Seal AdChoices