Who should not take Promethazine HCL?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • decreased function of bone marrow
  • parkinson symptoms
  • neuroleptic malignant syndrome
  • lower seizure threshold
  • closed angle glaucoma
  • very rapid heartbeat - torsades de pointes
  • prolonged QT interval on EKG
  • abnormal EKG with QT changes from birth
  • decreased lung function
  • stenosing peptic ulcer
  • narrowing of opening between stomach and small intestine
  • stomach or intestine blockage
  • liver problems
  • blockage of urinary bladder
  • enlarged prostate
  • Coma
  • seizures
  • Temporarily Stops Breathing While Sleeping
  • High Amount of Bilirubin in the Blood
  • chronic obstructive lung disease
  • chronic idiopathic constipation


  • Phenothiazines

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.