Adenosine; Hexobendine; Regadenoson/Xanthine Derivatives Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Xanthine derivatives, including caffeine, prevent adenosine, hexobendine and regadenoson from working.

What might happen:

Your adenosine or hexobendine may not work as well.

What you should do about this interaction:

Adenosine and regadenoson are usually used during surgical procedures or in a hospital. Hexobendine is usually used for heart disease. If you are to have either inpatient or outpatient surgery or tests, are to be admitted to the hospital, or started on hexobendine, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals. If you are scheduled for a cardiac stress test, your doctor may instruct you to avoid caffeine before your test.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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  • 3.Adenoscan (adenosine) US prescribing information. Astellas Pharma US, Inc. August, 2014.
  • 4.Lexiscan (regadenoson) US prescribing information. Astellas Pharma US, Inc. May, 2018.
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  • 7.Taddei S, Pedrinelli R, Salvetti A. Theophylline is an antagonist of adenosine in human forearm arterioles. Am J Hypertens 1991 Mar;4(3 Pt 1):256-9.
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  • 10.Smits P, Schouten J, Thien T. Respiratory stimulant effects of adenosine in man after caffeine and enprofylline. Br J Clin Pharmacol 1987 Dec; 24(6):816-9.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.