DULOXETINE HCL Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

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    If experienced, these tend to have a Less Severe expression i

    • dry mouth
    • constipation
    • drowsiness
    • dizziness
    • difficulty sleeping
    • low energy
    • excessive sweating
    • nausea
    • diarrhea

    INFREQUENT side effects

    If experienced, these tend to have a Severe expression i

    • fainting

    If experienced, these tend to have a Less Severe expression i

    • altered interest in having sexual intercourse
    • problems with ejaculation
    • agitation
    • blurred vision
    • indigestion
    • the inability to have an erection
    • itching
    • muscle spasm
    • sensation of spinning or whirling
    • a sleep disorder
    • chills
    • muscle tremors
    • temporary redness of face and neck
    • decreased appetite
    • weight gain
    • weight loss
    • headache
    • yawning
    • cough
    • gas
    • urination during the night
    • low energy and weakness
    • generalized weakness
    • orgasm problems
    • abnormal dreams
    • anxious feelings

    RARE side effects

    If experienced, these tend to have a Severe expression i

    • a condition with low thyroid hormone levels
    • a high prolactin level
    • a disorder with excess antidiuretic hormone called syndrome of inappropriate antidiuretic hormone
    • low amount of sodium in the blood
    • an increased risk of bleeding
    • manic behavior
    • a form of mania that has a lower severity of symptoms
    • suicidal behavior
    • suicidal thoughts
    • myoclonus, quick and involuntary muscle jerks
    • extrapyramidal disease, a type of movement disorder
    • serotonin syndrome, a type of disorder with high serotonin levels
    • high blood pressure
    • extremely high blood pressure
    • a heart attack
    • supraventricular tachycardia
    • inflammation of blood vessels in the skin
    • bleeding
    • a feeling of throat tightness
    • a stomach ulcer
    • a type of stomach irritation called gastritis
    • inflammation of the large intestine
    • liver damage
    • liver failure
    • inflammation of the liver called hepatitis
    • a blockage of the bile duct that resulting in high bilirubin levels
    • acute inflammation of the pancreas
    • bleeding of the stomach or intestines
    • erythema multiforme, a type of allergic skin reaction
    • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
    • hallucinations
    • seizures
    • a feeling of restlessness with inability to sit still
    • a type of abnormal movement disorder called dyskinesia
    • high amount of bilirubin in the blood
    • abnormal liver function tests
    • a broken bone
    • a significant type of allergic reaction called anaphylaxis
    • a type of allergic reaction called angioedema
    • secondary angle-closure glaucoma, a type of eye disorder
    • accidental falls
    • takotsubo cardiomyopathy
    • a high alanine transaminase level
    • a high aspartate transaminase level

    If experienced, these tend to have a Less Severe expression i

    • high cholesterol
    • confusion
    • grinding of the teeth
    • aggressive behavior
    • dry eye
    • dilated pupils
    • ringing in the ears
    • an earache
    • orthostatic hypotension, a form of low blood pressure
    • a sore throat
    • stomatitis, a condition with painful swelling and sores inside the mouth
    • breastmilk production not associated with childbirth or nursing
    • bleeding not related to menstrual period
    • increased sensitivity of the skin to the sun
    • contact dermatitis, a type of skin rash that occurs from contact with an offending substance
    • hives
    • lockjaw
    • muscle twitching
    • taste impairment
    • abnormal manner of walking
    • numbness
    • excessive thirst
    • a type of speech disorder called dysarthria
    • nosebleed
    • bad breath
    • heart throbbing or pounding
    • burping
    • difficult or painful urination
    • excess urination
    • high blood sugar
    • a feeling of pins and needles on skin
    • hematoma, a collection of blood outside of the blood vessels
    • a feeling of general discomfort called malaise
    • irritability
    • restless legs syndrome, an extreme discomfort in the calf muscles when sitting or lying down
    • a sensation of feeling cold
    • indifferent behavior
    • pain in the testicles
    • night sweats
    • a delay when starting to urinate
    • pain in the muscles or bones
    • fast heartbeat

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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.