Lamotrigine/Estrogen-Containing Contraceptives Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Estrogen increases how quickly your body removes lamotrigine. Lamotrigine may increase how quickly your body removes your contraceptive medicine.
What might happen:
The amount of lamotrigine and estrogen in your blood may be lowered. You may have more seizures if you are taking lamotrigine for a seizure disorder. If you are taking an estrogen-containing contraceptive, it may not work as well to prevent pregnancy.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you notice any changes in your seizure frequency. Inform your doctor if you have any changes in your menstrual cycle, such as break-through bleeding. This may be a sign that your estrogen-containing contraceptive may not be working.If you are taking carbamazepine, phenytoin, phenobarbital, primidone, ritonavir, or rifampin, then your doctor will probably not need to adjust your lamotrigine dose.If you are not taking one of these medicines, then your doctor may need to adjust the dose of your lamotrigine if you start or stop taking your estrogen-containing contraceptive. Make sure that the doctor prescribing your lamotrigine knows if you start or stop taking estrogen-containing contraceptives. If you start an estrogen containing contraceptive your lamotrigine dose may need to be increased to maintain effectiveness. When you stop an estrogen containing contraceptive your lamotrigine dose may need be decreased to lower the risk for lamotrigine side effects.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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