Riociguat/Nitrates & Nitric Oxide Donors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the effects of your nitrate medicine may increase.

What might happen:

Your blood pressure may decrease and cause weakness, fatigue, dizziness, loss of consciousness. You may also experience a heart attack or stroke.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) right away about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Adempas (riociguat) US prescribing information. Bayer HealthCare Pharmaceuticals, Inc. January 17, 2017.
  • 2.Nitrostat (nitroglycerin) US prescribing information. Pfizer January, 2017.