Piperacillin-Tazobactam/Vancomycin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of your medicines may damage your kidneys.

What might happen:

Taking these medicines together may increase the risk of damage to your kidneys.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to adjust your medicines. Be sure to keep all laboratory appointments and let your doctor know if you notice a change in the amount of urine you are making.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicines before checking with them first.

  • 1.Zosyn (piperacillin and tazobactam) US prescribing information. Wyeth Pharmaceuticals May, 2017.
  • 2.Vancocin (vancomycin) injection US prescribing information. Baxter Healthcare September, 2017.
  • 3.Hammond DA, Smith MN, Li C, Hayes SM, Lusardi K, Bookstaver PB. Systematic Review and Meta-Analysis of Acute Kidney Injury Associated with Concomitant Vancomycin and Piperacillin/tazobactam. Clin Infect Dis 2017 Mar 1;64(5):666-674.
  • 4.Navalkele B, Pogue JM, Karino S, Nishan B, Salim M, Solanki S. Risk of Acute Kidney Injury in Patients on Concomitant Vancomycin and Piperacillin-Tazobactam Compared to Those on Vancomycin and Cefepime. Clin Infect Dis 2017 Jan 15;64(2):116-123.
  • 5.Rutter WC, Burgess DR, Talbert JC, Burgess DS. Acute kidney injury in patients treated with vancomycin and piperacillin-tazobactam: A retrospective cohort analysis. J Hosp Med 2017 Feb;12(2):77-82.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.