What should I Know Regarding Pregnancy, Nursing and Administering DEFERASIROX to Children or the Elderly?

If you are pregnant

  • Not Recommended:
  • If you are nursing

  • Precaution: POTENTIAL FOR IRON DEPLETION IN INFANT.
  • If you are an adult over 60

  • management or monitoring precaution: General-Elderly have increased risk for adverse effects. Renal-Contraindicated with CrCL<40mL/min. Reduce dose by 50% for CrCL=40-60 mL/min. Hepatic-Risk for worsened hepatic impairment and failure. Monitor LFTs closely. Gastrointestinal-GI bleed risk. Hematologic-Caution in high risk myelodysplastic syndromes due to increased incidence of toxicities.
  • Pediatric use

  • Severe Precaution: Toxicity with impaired or immature renal function. No safety and efficacy established age < 2 years.
  • Severe Precaution: Interrupt for volume depleting illness (vomiting, diarrhea, decreased oral intake) and monitor renal and hepatic function. Monitor auditory and ophthalmic function. Monitor serum ferritin monthly to assess treatment response and minimize the risk of overchelation.
  • Drug Survey

    Are you currently using deferasirox?

    This survey is being conducted by the WebMD marketing sciences department.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.