Digoxin/Penicillamine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known.

What might happen:

Your blood levels of digoxin may decrease.

What you should do about this interaction:

If you experience an increase in heartbeat; swelling of your ankles, feet, or hands; or breathing problems, contact your doctor. It may be necessary to adjust the dose of your medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Moezzi B, Fatourechi V, Khozain R, Eslami B. The effect of penicillamine on serum digoxin levels. Jpn Heart J 1978 May;19(3):366-75.
  • 2.Moezzi B, Khozein R, Pooymehr F, Shakibi JG. Reversal of digoxin-induced changes in erythrocyte electrolyte concentrations by penicillamine in children. Jpn Heart J 1980 May;21(3):335-9.
  • 3.Lanoxin (digoxin) Tablets US prescribing information. Covis Pharmaceuticals, Inc. August, 2018.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.